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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RSK3 Antibody   

RSK3 Antibody

Rabbit Monoclonal Antibody

  • IHC - RSK3 Antibody AJ1699a
    Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using anti-Rsk3 RabMAb (Cat. #AJ1699a).
  • WB - RSK3 Antibody AJ1699a
    Western blot analysis on HeLa cell lysate using anti-RSK3 RabMAb (Cat. #AJ1699a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15349
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names E202
Calculated MW 83239 Da
Gene ID 6196
Other Names Ribosomal protein S6 kinase alpha-2, S6K-alpha-2, 90 kDa ribosomal protein S6 kinase 2, p90-RSK 2, p90RSK2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, Ribosomal S6 kinase 3, RSK-3, pp90RSK3, RPS6KA2, MAPKAPK1C, RSK3
Target/Specificity A synthetic peptide corresponding to residues surrounding threonine 353 and threonine 356 of human RSK3 was used as an immunogen.
Dilution IHC~~1:50~1:100
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRSK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RPS6KA2
Synonyms MAPKAPK1C, RSK3
Function Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Cellular Location Nucleus. Cytoplasm
Tissue Location Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate
Research Areas
Citations (0)

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Rsk-3 is a member of a family of 90-kDa ribosomal protein S6 kinases, which includes Rsk-1, Rsk-2 and Rsk-3. These are broadly expressed serine/threonine protein kinases (1) that are activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). Rsk-3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, phosphorylates potential nuclear targets, and may have a unique upstream activator (3). Several sites, such as Ser380, Thr359, Ser363 and Thr573, are important for its activation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).


1. Dalby, K.N., et al. Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90rsk That Are Inducible by MAPK. J. Biol. Chem. 273: 149
2. Frodin, M. and S. Gammeltoft. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol. Cell. Endocrinol. 151: 65
3. Zhao, Y., et al. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol Cell Biol. 15: 4353
4. Chen, R., et al. Phosphorylation of the c-Fos Transrepression Domain by Mitogen-Activated Protein Kinase and 90-kDa Ribosomal S6 Kinase. Proc. Natl. Acad. Sci. USA 90: 10952

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Cat# AJ1699a
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