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SHP-1 Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - SHP-1 Antibody (C-term) AJ1715a
    A. Western blot analysis of anti-SHP-1 (C-term) RabMAb (Cat. #AJ1715a) 1:1,000 dilution A- A431 B- Jurkat C- K562
  • IHC - SHP-1 Antibody (C-term) AJ1715a
    B. Immunohistochemical analysis of paraffin-embedded human lymph node using anti-SHP-1 (C-term) RabMAb (Cat. #AJ1715a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P29350
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y476
Calculated MW 67561 Da
Gene ID 5777
Other Names Tyrosine-protein phosphatase non-receptor type 6, Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, PTPN6, HCP, PTP1C
Target/Specificity A synthetic peptide corresponding to residues in the C-term of human DHP-1 was used as immunogen. This antibody is predicted to detect isoforms 2 and 3 based on sequence analysis.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSHP-1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPN6
Synonyms HCP, PTP1C
Function Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Cellular Location Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.
Tissue Location Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells
Research Areas
Citations (0)

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SHP-1 (also called PTP1C, SH-PP1, HCP, SHP and PTPN6) is a protein tyrosine phosphatase (PTP) predominantly expressed in hematopoietic cells, and regulates multiple signaling pathways involved in hematopoietic cell growth, differentiation and activation (1). After cell stimulation, SHP-1 (as well as SHP-2), translocate from cytosol to plasma membrane and bind to the tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). SHP-1 has been involved in the negative regulation of various growth promoting receptors including receptor tyrosine kinase (c-Kit, CSF-1, EGF), cytokine receptors (IL-3, IFN-a/b) and other tyrosine based receptor CD22, B & T cell Ag receptor, Lck, Zap-70 and Vav (3-5).


1. Banville, D.; Stocco, R.; Shen, S.-H. : Genomics 27: 165-173, 1995.
2. Klingmuller, U., Lorentz, U., Cantley, L. C., Neel, B. G., and Lodish, H. F. (1995) Cell 80, 729-738
3. Yi, T., J. Ihle. 1993. Mol. Cell. Biol. 13:3350.
4. Chen, H. E., S. Chang, T. Trub, B. G. Neel. 1996. Mol. Cell. Biol. 16:3685
5. Tomic, S., R. U. Greise, R. Lammers, A. Kharitonenkov, E. Imyanitov, A. Ullrich, F. Bohmer. 1995. J. Biol. Chem. 270:21277

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Cat# AJ1715a
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