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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ST13/HIP Antibody   

ST13/HIP Antibody

Rabbit Monoclonal Antibody

  • WB - ST13/HIP Antibody AJ1736a
    A. Western blot analysis on (A) 293T and (B) SW480 cell lysates using anti-ST13/HIP RabMAb (Cat. #AJ1736a), dilution 1:100,000.
  • IHC - ST13/HIP Antibody AJ1736a
    B.Immunohistochemical analysis of paraffin-embedded human colonic adenocarcinoma tissue using anti-ST13/HIP RabMAb (Cat. #AJ1736a).
  • IHC - ST13/HIP Antibody AJ1736a
    C. Immunohistochemical analysis of paraffin-embedded human normal colon tissue using anti-ST13/HIP RabMAb (Cat. #AJ1736a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50502
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP3264
Calculated MW 41332 Da
Gene ID 6767
Other Names Hsc70-interacting protein, Hip, Aging-associated protein 2, Progesterone receptor-associated p48 protein, Protein FAM10A1, Putative tumor suppressor ST13, Renal carcinoma antigen NY-REN-33, Suppression of tumorigenicity 13 protein, ST13, AAG2, FAM10A1, HIP, SNC6
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human Hsc70 Interacting Protein/HIP was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsST13/HIP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ST13
Synonyms AAG2, FAM10A1, HIP, SNC6
Function One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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ST13/HIP is a cytoplasmic co-chaperone involved in the regulation of Hsc70 chaperone activity and the maturation of progesterone receptor. ST13/HIP is made of two structural and functional domains, an NH2-terminal domain, responsible for the dimerization and the overall asymmetry of the molecule, and a COOH-terminal globular domain, both involved in Hsc70 and unfolded protein binding (1). By collaborating with other positive co-factors such as Hsp40 and the Hsp70-Hsp90 organizing protein (Hop), or competing with negative co-factors such as Bcl2-associated athanogen 1 (Bag1), ST13/HIP facilitates may facilitate the chaperone function of Hsc/Hsp70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and regulators of proliferation or apoptosis (2).


1. Velten M, et al. J Biol Chem. 277(1):259-66, 2002
2. Shi ZZ, et al. J Zhejiang Univ Sci B. 8(3):170-6, 2007

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Cat# AJ1736a
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