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Stat-2 Antibody

Rabbit Monoclonal Antibody

  • WB - Stat-2 Antibody AJ1738a
    A. Western blot analysis on K562 cell lysate using anti-Stat-2 RabMAb (Cat. #AJ1738a), dilution 1:500.
  • IHC - Stat-2 Antibody AJ1738a
    B. Immunohistochemical analysis of paraffin-embedded human thyroid cancer using anti-Stat-2 RabMAb (Cat. #AJ1738a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P52630
Reactivity Human, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y141
Calculated MW 97916 Da
Gene ID 6773
Other Names Signal transducer and activator of transcription 2, p113, STAT2
Target/Specificity A synthetic peptide corresponding to residues near N-terminus of human Stat-2 was used as immunogen. This antibody detects both long and short forms of Stat-2.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsStat-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAT2
Function Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).
Cellular Location Cytoplasm. Nucleus Note=Translocated into the nucleus upon activation by IFN- alpha/beta.
Research Areas
Citations (0)

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Stat-2 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleus. Stat-2 is one of seven members of the Signal transducer and activators of transcription (Stats) family. Stat-2 is phosphorylated at Tyr690 by JAKs(1-3). Additionally, upon activation, Stat-2 will form a multiprotein DNA-binding complex with Stat-1 and ISGF3γp48 (4). This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements.


1. Silvennoinen, O., Ihle, J. N., Schlessinger, J., and Levy, D. E. (1993) Nature 366, 583-585
2. Darnell, J. E., Jr. (1997) Science 277, 1630-1635
3. Fu, X.-Y., Kessler, D. S., Veals, S. A., Levy, D. E., and Darnell, J. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 8555-8559
4. Veals, S. A., Schindler, C., Leonard, D., Fu, X. Y., Aebersold, R., Darnell, J. E., and Levy, D. E. (1992) Mol. Cell. Biol. 12, 3315-3324

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Cat# AJ1738a
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