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Synapsin I Antibody Phospho (pS9)

Rabbit Monoclonal Antibody

  • WB - Synapsin I Antibody Phospho (pS9) AJ1749b
    A. Western blot analysis on human brain tissue lysates using anti-Phospho-Synapsin I (pS9) RabMAb (Cat. #AJ1749b), 1:5000 dilution. Cells were either (A) untreated (B) treated with AP
  • IHC - Synapsin I Antibody Phospho (pS9) AJ1749b
    B. Immunohistochemical analysis of paraffin-embedded human brain using anti-phospho Synapsin (pS9) RabMAb (Cat. #AJ1749b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17600
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP2162Y
Calculated MW 74111 Da
Gene ID 6853
Other Names Synapsin-1, Brain protein 41, Synapsin I, SYN1
Target/Specificity A synthetic phospho-peptide corresponding to residues surrounding serine 9 of human synapsin I protein.
Dilution WB~~1:2000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynapsin I Antibody Phospho (pS9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYN1
Function Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Cellular Location Cell junction, synapse. Golgi apparatus
Research Areas
Citations (0)

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Synapsin I is a member of neuron-specific phosphoproteins that associate with synaptic vesicles (1). Three mammalians synapsins have been identified, Synapsin I, II and III. Generated by differential splicing, Synapsin Ia and Synapsin Ib differ in their Carboxyl termini (2). Synapsin I also functions in binding synaptic vesicles to several elements of the cytoskeleton including actin filaments, microtubules and spectrin. (3) Fairly abundant protein of the brain (0.4%), Synapsin I is best known to be CaM kinase II substrate in addition to cAMP-dependent protein kinase. (4) Phosphorylation at site Ser 566 and Ser 603 by CaM kinase II will cause a 5 fold decrease in the affinity of synaptic vesicles binding. A phosphorylation of serine 9 on synapsin amino-terminal can lead to inhibition in its binding to phospholipids and dissociation of synapsins from synaptic vesicles.


1. Greengard P., et al. Science 259:780
2. S
3. Bahler M, Greengard P, Nature 326:704
4. Huttner WB., et al. J Biol Chem 256:1482
5. Schiebler, W, et al. J. Biol Chem. 261, 8383-8390, 1986.

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Cat# AJ1749b
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