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Synapsin II Antibody

Rabbit Monoclonal Antibody

  • WB - Synapsin II Antibody AJ1750a
    A.Western blot analysis on fetal brain cell lysate using anti-Synapsin II RabMAb (Cat. #AJ1750a), dilution 1:20,000.
  • IHC - Synapsin II Antibody AJ1750a
    B. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-SynapsinII RabMAb (Cat. #AJ1750a).
  • IF - Synapsin II Antibody AJ1750a
    C. Immunofluorescent staining of Sh-SY-5Y cells using anti-SynapsinII RabMAb (Cat. #AJ1750a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92777
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3277
Calculated MW 62996 Da
Gene ID 6854
Other Names Synapsin-2, Synapsin II, SYN2
Target/Specificity A synthetic peptide corresponding to residues in human Synapsin II was used as an immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynapsin II Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYN2
Function Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).
Cellular Location Cell junction, synapse.
Tissue Location Central and peripheral nervous systems.
Research Areas
Citations (0)

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The synapsins are a family of at least five proteins that are specifically associated with the cytoplasmic surface of synaptic vesicles (1, 2). They are neuron-specific phosphoproteins that selectively bind to small synaptic vesicles in the presynaptic nerve terminal (3). The synapsins are implicated in neurotransmitter release and synaptogenesis, processes believed to be aberrant in several neuropsychiatric diseases (1). Synapsin II has been reported to specifically be involved in the formation and maintenance of synapses in hippocampal neurons (4). It has also been found to play a distinct role in neuronal development, as a study reported that the deletion of synapsin II greatly retarded axon formation, and the deletion of synapsin I retarded synapse formation (5). Synapsin II was furthermore suggested to participate in cytoskeletal organization during the early stages of nerve cell development (6).


1. Porton B, et al. DNA Seq. 10(1):49-54,1999
2. Gerald Thiel, et al. Brain Pathology 3(1):87 - 95, 2008
3. Gerald Thiel, et al. The Journal of Bio.Chemistry 265(27):16527-16533, 1990
4. A. Ferreira, et al. PNAS 92(20):9225-9229, 1995
5. A. Ferreira, et al. Mol Med. 4(1): 22-28, 1998
6. A. Ferreira, et al. Science 264(5161):977 - 979, 1994

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Cat# AJ1750a
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