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TC10 Antibody

Rabbit Monoclonal Antibody

  • WB - TC10 Antibody AJ1758a
    A. Western blot analysis on 293 cell lysate using anti-TC10 RabMAb (Cat. #AJ1758a), dilution 1:1,000.
  • IF - TC10 Antibody AJ1758a
    B. Immunofluorescent staining of HeLa cells using anti-TC10 RabMAb (Cat. #AJ1758a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17081
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names Y304
Calculated MW 22659 Da
Gene ID 23433
Other Names Rho-related GTP-binding protein RhoQ, Ras-like protein TC10, Ras-like protein family member 7A, RHOQ, ARHQ, RASL7A, TC10
Target/Specificity A synthetic peptide corresponding to the third GTP unit of human TC10 was used as immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTC10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ARHQ, RASL7A, TC10
Function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.
Cellular Location Cytoplasm. Cell membrane; Lipid-anchor
Research Areas
Citations (0)

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TC10 is a member of the Rho family of GTP-binding proteins and is closely related to Cdc42 and Rac 1. Cycling between inactive and active GTP-bound state, active TC10 can directly interact with Cdc42 kinase, p21-activated protein kinases as well as other kinases (1). Constitutive expression of active TC10 mutants (TC10/Q75L) in fibroblast decrease actin stress fiber and formation of plasma membrane microspikes, while wild type TC10 has no effect on fibroblast cell morphology (2). Mostly expressed in adipose and muscle tissues, TC10 has been found to be activated by C3G (from the insulin pathway) in adipocytes (3).


1. Neudauer, C.L., Joberty, G., Tatsis, N., and Macara, I.G. (1998). Curr. Biol. 8, 1151-1160
2. Murphy, G.A., Solski, P.A., Jillian, S.A., Perez de la Ossa, P., D'Eustachio, P., Der, C.J., and Rush, M.G. (1999). Oncogene 18, 3831-3845
3. Baumann , C.A., Ribon, V., Kanzaki, M., Thurmond, D.C., Mora, S., Shigematsu, S., Bickel, P.E., Pessin, J.E., and Saltiel, A.R. (2000). Nature 407, 202-207

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Cat# AJ1758a
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