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TCP1 beta Antibody

Rabbit Monoclonal IgG

  • WB - TCP1 beta Antibody AJ1762a
    Western blot analysis on (A) HeLa, (B) MCF-7, and (C) Daudi cell lysates using anti-TCP1 beta RabMAb (Cat. #AJ1762a).
  • IHC - TCP1 beta Antibody AJ1762a
    Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-TCP1 beta RabMAb (Cat. #AJ1762a).
  • IHC - TCP1 beta Antibody AJ1762a
    Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-TCP1 beta RabMAb (Cat. #AJ1762a).
  • IF - TCP1 beta Antibody AJ1762a
    Immunofluorescent staining of HeLa cells using anti-TCP1 beta RabMAb (Cat. #AJ1762a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78371
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR4084
Calculated MW 57488 Da
Gene ID 10576
Other Names T-complex protein 1 subunit beta, TCP-1-beta, CCT-beta, CCT2, 99D81, CCTB
Target/Specificity A synthetic peptide corresponding to residues on the C-terminus in human TCP1 Beta was used as an immunogen.
Dilution WB~~1:2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTCP1 beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCT2
Synonyms 99D8.1, CCTB
Function Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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T-complex polypeptide 1 subunit beta (TCP1 beta) is a cytosolic molecular chaperone that belongs to the chaperonin-containing TCP1 (CCT) complex (1). The CCT complex is composed of eight subunits that assist in the folding of actin, tubulin, and other cytosolic proteins (1). The sequence differences among the CCT subunits are located mainly in their apical domains, suggesting some degree of specificity towards substrate binding (2). TCP1 beta plays a role in the folding of newly translated proteins in the cytosol (3). Major cytoskeletal proteins such as actin and tubulin, depend on CCT to maintain the integrity of the microfilament and microtubule-based cytoskeletal systems (4). The beta-tubulin/TCP1 beta complex may serve as an effective chemotherapeutic target for treating tumors overexpressing TCP1 beta (5).


1. Yokota et al. Eur J Biochem. 268(17):4664-73, 2001. 2. Llorca et al. EMBO J. 20(15):4065-75, 2001. 3. Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: { 186980}: {5/23/2003}: . World Wide Web URL: 4. Brackley et al. Cell Stress Chaperones. 14(1):23-31, 2009. 5. Lin et al. Cancer Res. 69(17):6879-88, 2009.

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Cat# AJ1762a
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