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TEC Antibody

Rabbit Monoclonal Antibody

  • WB - TEC Antibody AJ1764a
    A. Western blot analysis on Jurkat cell lysate using anti-Tec RabMAb (Cat. #AJ1764a) 1:10,000 dilution
  • IHC - TEC Antibody AJ1764a
    B. Immunohistochemical analysis of paraffin-embedded human ovary carcinoma using anti-Tec RabMAb (Cat. #AJ1764a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42680
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names Y398
Calculated MW 73581 Da
Gene ID 7006
Other Names Tyrosine-protein kinase Tec, TEC, PSCTK4
Target/Specificity A synthetic peptide corresponding to residues in the PH domain of human Tec was used as immunogen.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTEC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TEC
Synonyms PSCTK4
Function Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity).
Tissue Location Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages
Research Areas
Citations (0)

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Tec is a member of the Tec family of non-receptor protein-tyrosine kinase (PTK) which also includes Btk, emtk/itk/Tsk, Rlk/Txx and Bmx (1). Tec is composed of a pleckstrin domain (PH), an SH3 and SH2 domain, a catalytic kinase domain and a Tec homology domain (TH) (2). Tecs TH domain interacts with the SH3 domain of Grb2, Src family PTKs ( Fyn, Lyn, and Hck), Vav, and c-Kit. Tec is mostly expressed in hematopoietic cells. Tecs SH3 domain interacts with DC28 and has been shown to phosphorylate p62 dok, CD28 substrate (3). Tec can phosphorylate Jak kinase in hematopoietic cells (4) and can also be phosphorylated by Src member Lyn on multiple tyrosine residues (5).


1. Bolen, J. B. (1995) Curr. Opin. Immunol. 7, 306-311
2. Vihinen, M., Nilsson, L., and Smith, C. I. (1994) FEBS Lett. 350, 263-265
3. Wen-Chin Yang, Marguerite Ghiotto, Bernadette Barbarat, and Daniel Olive. J Biol Chem, Vol. 274, Issue 2, 607-617, January 8, 1999
4. Yamashita et al.(1998) Blood 91, 1496-1507
5. H Mano, Y Yamashita, A Miyazato, Y Miura and K Ozawa. 1996, The FASEB Journal, Vol 10, 637-642.

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Cat# AJ1764a
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