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TNNT2 Antibody

Rabbit Monoclonal

  • WB - TNNT2 Antibody AJ1779a
    A. Western blot analysis on (A) human heart, (B) human skeletal muscle and (C) human heart lysates using anti-TNNT2 RabMAb (Cat. #AJ1779a).
  • IHC - TNNT2 Antibody AJ1779a
    B.Immunohistochemical analysis of paraffin-embedded human cardiac muscle using anti-TNNT2 RabMAb (Cat. #AJ1779a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P45379
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3695
Calculated MW 35924 Da
Gene ID 7139
Other Names Troponin T, cardiac muscle, TnTc, Cardiac muscle troponin T, cTnT, TNNT2
Target/Specificity A synthetic peptide corresponding to residues in human TNNT2 was used as an immunogen.
Dilution WB~~1:100000~500000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTNNT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNNT2
Function Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Tissue Location Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart
Research Areas
Citations (0)

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The troponin complex is located on the thin filament of striated muscle and is composed of three component polypeptides: troponin T (TNNT1; TNNT2), troponin I (TNNI1; TNNI2; TNNI3), and troponin C (TNNC) (1). Troponin T type 2 (TNNT2) is a cardiac troponin T isoform expressed in the human heart, that is essential for calcium-regulated myofibrillar ATPase activity (2). Troponin T (TnT) anchors the complex to the thin filaments in vertebrate striated muscle, and functions as a regulatory system for muscle contraction in response to changes to intracellular calcium ion concentration (3). All subunits of Tnnt2 have been associated with hypertrophic cardiomyopathy (HCM) (4).


1. Townsend PJ, et al. Genomics. 21(2):311-6, 1994 2. Anderson PA, et al. Circ Res. 76(4):681-6, 1995 3. Gian-Franco Sferrazza, et al. Biochem Biophys Res Commun. 357(1): 32-37, 2007 4. Gomes AV, et al. Mol Cell Biochem. 263(1-2):115-29, 2004

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Cat# AJ1779a
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