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TPH1 Antibody

Rabbit Monoclonal Antibody

  • WB - TPH1 Antibody AJ1784a
    A. Western blot analysis on THP-1 cell lysate using anti-TPH1 RabMAb (Cat. #AJ1784a), dilution 1:500
  • IHC - TPH1 Antibody AJ1784a
    B. Immunohistochemical staining of paraffin-embedded human urinary bladder carcinoma using anti-TPH-1 RabMAb (Cat. #AJ1784a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17752
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1311Y
Calculated MW 50985 Da
Gene ID 7166
Other Names Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1, TPH1, TPH, TPRH, TRPH
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human TPH1 was used as an immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTPH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TPH1
Synonyms TPH, TPRH, TRPH
Tissue Location Isoform 2 seems to be less widely expressed than isoform 1
Research Areas
Citations (0)

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Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and might be related to the pathogenesis of major depression (MD). Two isoforms are known, TPH1 and TPH2. (1). TPH1 is phosphorylated by cAMP-dependent protein kinase A (2). Recently, it has been shown that expression of the TPH1 gene is increased in lungs and pulmonary endothelial cells from patients with idiopathic pulmonary arterial hypertension. Results indicate that TPH1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxia-induced pulmonary vascular remodeling. In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy (3).


1. Gizatullin R, et al. Biol Psychiatry 59(4):295-300, 2006.
2. McKinney J, et al. J Neurochem 92(2):311-20, 2005.
3. Morecroft I, et al. Hypertension 49(1):232-6, 2007

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Cat# AJ1784a
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