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Troponin-1 Antibody

Rabbit Monoclonal Antibody

  • WB - Troponin-1 Antibody AJ1795a
    A. Western blot analysis on fetal heart cell lysate using anti-Troponin RabMAb (Cat. #AJ1795a), dilution 1:1,000,000
  • IHC - Troponin-1 Antibody AJ1795a
    B. Immunohistochemical staining of paraffin-embedded human cardiac muscle using anti-Troponin RabMAb (Cat. #AJ1795a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19429
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1106Y
Calculated MW 24008 Da
Gene ID 7137
Other Names Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Troponin 1 was used as an immunogen.
Dilution WB~~1:1000000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTroponin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNNI3
Synonyms TNNC1
Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Research Areas
Citations (0)

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Troponin I, one of 3 subunits that form the troponin complex of the thin filaments of striated muscle, is the inhibitory component of troponin, the thin filament regulatory complex in striated muscle. Separate genes encode cardiac-specific fast and slow skeletal-specific isoforms of this protein (1). Unlike other contractile proteins, the cardiac isoform of troponin I (TnIc) is expressed only in cardiac muscle and therefore offers a model for cardiac-specific expression. It is also subject to developmental regulation with increased expression occurring at the time of birth (2). TnIc, a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes. Studies report that TnIc is elevated in severe heart failure and may predict adverse outcomes (3).


1. Hunkeler NM, et al. Circ Res. 69(5):1409-14, 1991.
2. Bhavsar PK, et al. Genomics 35(1):11-23, 1996.
3. Horwich TB, et al. Circulation 108(7):833-8, 2003.

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Cat# AJ1795a
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