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Tryptophanyl-tRNA Synthase Antibody

Rabbit Monoclonal Antibody

  • WB - Tryptophanyl-tRNA Synthase Antibody AJ1796a
    Western blot analysis on (A) JAR and (B) 293T cell lysates using anti-Tryptophanyl-tRNA synthetase RabMAb (Cat. #AJ1796a).
  • IF - Tryptophanyl-tRNA Synthase Antibody AJ1796a
    Immunofluorescent staining of HeLa cells using anti-Tryptophanyl-tRNA synthetase RabMAb (Cat. #AJ1796a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23381
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3424
Calculated MW 53165 Da
Gene ID 7453
Other Names Tryptophan--tRNA ligase, cytoplasmic, Interferon-induced protein 53, IFP53, Tryptophanyl-tRNA synthetase, TrpRS, hWRS, T1-TrpRS, T2-TrpRS, WARS, IFI53, WRS
Target/Specificity A synthetic peptide corresponding to residues at the C terminus of human Tryptophanyl-tRNA synthetase was used as an immunogen.
Dilution WB~~1:50000~200000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTryptophanyl-tRNA Synthase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms IFI53, WRS
Function Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
Cellular Location Cytoplasm.
Citations (0)

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Tryptophanyl-tRNA synthetase (TrpRS) is a dual function enzyme that acts in protein biosynthesis and angiogenesis (1). TrpRS is a Zn2+-dependent, dimeric, class I aminoacyl-tRNA synthetase (2). Aminoacyl-tRNAs play a major role in connecting amino acids with nucleotide triplets in tRNAs (3). TrpRS catalyzes the aminoacylation of tRNA(trp) with tryptophan. TrpRS exists in two different forms: cytoplasmic (WARS) and mitochondrial (WARS2) (2).


1. Ewalt and Schimmel. Biochemistry. 41:13344-9; 2002 2. Kisselev LL. Biochimie 75:1027-39; 1993 3. Lluis Ribas de Pouplana, et al. Proc. Natl. Acad. Sci. USA 93: 166-170, 1996

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Cat# AJ1796a
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