|Reactivity||Human, Monkey, Dog|
|Dilution||IHC-P (13-26 µg/ml)|
|Other Names||Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5, CNR2, CB2A, CB2B|
|Target/Specificity||Human CNR2 / CB2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CNR1 (60%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CNR2 / CB2 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon Note=Localizes to apical dendrite of pyramidal neurons|
|Tissue Location||Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Munro S.,et al.Nature 365:61-65(1993).
Liu Q.-R.,et al.Genes Brain Behav. 8:519-530(2009).
Bruess M.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Warren C.N.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Saravanan T.,et al.Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
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