|Reactivity||Human, Mouse, Hamster, Pig, Horse, Bovine, Guinea Pig|
|Dilution||IHC-P (3 µg/ml)|
|Other Names||Muscarinic acetylcholine receptor M4, CHRM4|
|Target/Specificity||Human CHRM4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CHRM4 / M4 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
Bonner T.I.,et al.Science 237:527-532(1987).
Bonner T.I.,et al.Neuron 1:403-410(1988).
Peralta E.G.,et al.EMBO J. 6:3923-3929(1987).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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