|Reactivity||Human, Rabbit, Horse|
|Dilution||IHC-P (9 µg/ml)|
|Other Names||Calcitonin receptor, CT-R, CALCR|
|Target/Specificity||Human Calcitonin Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CALCR / Calcitonin Receptor Antibody (Transmembrane Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
Gorn A.H.,et al.J. Clin. Invest. 90:1726-1735(1992).
Kuestner R.E.,et al.Mol. Pharmacol. 46:246-255(1994).
Albrandt K.,et al.Endocrinology 136:5377-5384(1995).
Frendo J.L.,et al.FEBS Lett. 342:214-216(1994).
Nishikawa T.,et al.FEBS Lett. 458:409-414(1999).
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