|Application ||IHC-P, ICC|
|Reactivity||Human, Mouse, Hamster, Monkey, Pig, Bovine, Dog|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR|
|Target/Specificity||Human GRPR. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ADAM28 (41%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GRPR Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Corjay M.H.,et al.J. Biol. Chem. 266:18771-18779(1991).
Xiao D.,et al.Gene 264:95-103(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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