|Application ||IHC-P, ICC|
|Reactivity||Human, Monkey, Horse|
|Dilution||ICC (7.5-10 µg/ml), IHC-P (4-8 µg/ml),|
|Other Names||Melanocortin receptor 4, MC4-R, MC4R|
|Target/Specificity||Human MC4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||MC4R / Melanocortin 4 Receptor Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Brain, placental, and gut tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Gantz I.,et al.J. Biol. Chem. 268:15174-15179(1993).
Mountjoy K.G.,et al.Mol. Endocrinol. 8:1298-1308(1994).
Kopatz S.A.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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