|Reactivity||Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Dog|
|Dilution||IHC-P (6 µg/ml)|
|Other Names||Glucagon-like peptide 1 receptor, GLP-1 receptor, GLP-1-R, GLP-1R, GLP1R|
|Target/Specificity||Human GLP1R. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PRPSAP2 (50%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GLP1R / GLP-1 Receptor Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Thorens B.,et al.Diabetes 42:1678-1682(1993).
Dillon J.S.,et al.Endocrinology 133:1907-1910(1993).
Graziano M.P.,et al.Biochem. Biophys. Res. Commun. 196:141-146(1993).
van Eyll B.,et al.FEBS Lett. 348:7-13(1994).
Wei Y.,et al.FEBS Lett. 358:219-224(1995).
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