|Reactivity||Human, Mouse, Rabbit, Hamster, Monkey, Pig, Chicken, Horse, Bovine, Dog|
|Dilution||IHC-P (4-8 µg/ml)|
|Other Names||Extracellular calcium-sensing receptor, CaSR, Parathyroid cell calcium-sensing receptor 1, PCaR1, CASR, GPRC2A, PCAR1|
|Target/Specificity||Human CASR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CASR/Calcium Sensing Receptor Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:7759551). The G-protein- coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta|
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Provided below are standard protocols that you may find useful for product applications.
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
Pearce S.H.S.,et al.Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
Garrett J.E.,et al.J. Biol. Chem. 270:12919-12925(1995).
Aida K.,et al.Biochem. Biophys. Res. Commun. 214:524-529(1995).
Freichel M.,et al.Endocrinology 137:3842-3848(1996).
Aida K.,et al.J. Clin. Endocrinol. Metab. 80:2594-2598(1995).
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