|Reactivity||Human, Mouse, Monkey, Pig, Bovine|
|Dilution||IHC-P (11 µg/ml)|
|Other Names||A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, 3.4.24.-, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAM-TS 11, ADAMTS-11, ADMP-2, Aggrecanase-2, ADAMTS5, ADAMTS11, ADMP2|
|Target/Specificity||Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.|
|Precautions||ADAMTS5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
Abbaszade I.,et al.J. Biol. Chem. 274:23443-23450(1999).
Hattori M.,et al.Nature 405:311-319(2000).
Hurskainen T.L.,et al.J. Biol. Chem. 274:25555-25563(1999).
Wang L.W.,et al.J. Biol. Chem. 284:30004-30015(2009).
Mosyak L.,et al.Protein Sci. 17:16-21(2008).
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