|Dilution||IHC-P (10 µg/ml)|
|Other Names||Sphingosine kinase 1, SK 1, SPK 1, 126.96.36.199, SPHK1, SPHK, SPK|
|Target/Specificity||Human SPHK1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||SPHK / SPHK1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N- dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.|
|Cellular Location||Cytoplasm. Nucleus. Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner|
|Tissue Location||Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle|
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Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
Melendez A.J.,et al.Gene 251:19-26(2000).
Nava V.E.,et al.FEBS Lett. 473:81-84(2000).
Pitson S.M.,et al.Biochem. J. 350:429-441(2000).
Van Veldhoven P.P.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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