|Application ||WB, IHC-P, ICC|
|Reactivity||Human, Monkey, Pig, Horse, Bovine|
|Dilution||IHC-P (38 µg/ml)|
|Other Names||Metabotropic glutamate receptor 3, mGluR3, GRM3, GPRC1C, MGLUR3|
|Target/Specificity||Human GRM3 / MGLUR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GRM3 / MGLUR3 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Makoff A.,et al.Brain Res. Mol. Brain Res. 40:55-63(1996).
Sartorius L.J.,et al.J. Neurochem. 96:1139-1148(2006).
Hillier L.W.,et al.Nature 424:157-164(2003).
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