|Dilution||IHC-P (10 µg/ml)|
|Other Names||Probable G-protein coupled receptor 62, G-protein coupled receptor GPCR8, hGPCR8, G-protein coupled receptor KPG_005, GPR62|
|Target/Specificity||Human GPR62. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GPR62 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Colocalizes with ARRB2 in the endosome (PubMed:28827538).|
|Tissue Location||Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
Lee D.K.,et al.Brain Res. Mol. Brain Res. 86:13-22(2001).
Urakawa I.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Sutterer S.M.,et al.Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
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