|Reactivity||Human, Monkey, Horse, Bovine, Dog|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||G-protein coupled receptor 26, GPR26|
|Target/Specificity||Human GPR26. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GPR26 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma|
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Provided below are standard protocols that you may find useful for product applications.
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
Jones G.,et al.Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
Boulay J.L.,et al.Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
Jones P.G.,et al.Biochim. Biophys. Acta 1770:890-901(2007).
Carter A.N.,et al.Mol. Cell. Probes 22:133-137(2008).
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