|Dilution||IHC-P (40 µg/ml)|
|Other Names||Galanin receptor type 2, GAL2-R, GALR-2, GALR2, GALNR2|
|Target/Specificity||Human GALR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GALR2 / Galanin Receptor 2 Antibody (Transmembrane Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
Bloomquist B.T.,et al.Biochem. Biophys. Res. Commun. 243:474-479(1998).
Borowsky B.,et al.Peptides 19:1771-1781(1998).
Fathi Z.,et al.Brain Res. Mol. Brain Res. 58:156-169(1998).
Kolakowski L.F. Jr.,et al.J. Neurochem. 71:2239-2251(1998).
Martin A.L.,et al.Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
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