|Dilution||IHC-P (12-16 µg/ml)|
|Other Names||Neuropeptides B/W receptor type 2, G-protein coupled receptor 8, NPBWR2, GPR8|
|Target/Specificity||Human NPBWR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except BCORL1 (39%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||NPBWR2 / GPR8 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Detected at high levels in caudate nucleus, hyppocampus and amygdala; at moderate levels in the adult brain, thalamus, parietal cortex, pituitary gland, adrenal gland and lymph nodes.|
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Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.
O'Dowd B.F.,et al.Genomics 28:84-91(1995).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Brezillon S.,et al.J. Biol. Chem. 278:776-783(2003).
Tanaka H.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:6251-6256(2003).
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