|Reactivity||Human, Mouse, Rabbit, Hamster, Monkey, Pig, Chicken, Horse, Bovine|
|Dilution||IHC-P (7 µg/ml)|
|Other Names||Dual specificity protein phosphatase 26, 126.96.36.199, 188.8.131.52, Dual specificity phosphatase SKRP3, Low-molecular-mass dual-specificity phosphatase 4, DSP-4, LDP-4, Mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP-8, Novel amplified gene in thyroid anaplastic cancer, DUSP26, DUSP24, LDP4, MKP8, NATA1, SKRP3|
|Target/Specificity||Human DUSP26. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||MKP-8 / DUSP26 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DUSP24, LDP4, MKP8, NATA1, SKRP3|
|Function||Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).|
|Cellular Location||Cytoplasm. Nucleus. Golgi apparatus.|
|Tissue Location||Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.|
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Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
Vasudevan S.A.,et al.Biochem. Biophys. Res. Commun. 330:511-518(2005).
Yu W.,et al.Oncogene 26:1178-1187(2007).
Takagaki K.,et al.Mol. Cell. Biochem. 296:177-184(2007).
Zama T.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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