|Reactivity||Human, Rabbit, Monkey, Bovine, Dog|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Protein Wnt-10a, WNT10A|
|Target/Specificity||Human WNT10A. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPRD (44%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||WNT10A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954). Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954). Required for normal hair follicle function (PubMed:28589954).|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
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Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.
Testa T.T.,et al.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
Rump A.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Kirikoshi H.,et al.Biochem. Biophys. Res. Commun. 283:798-805(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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