|Reactivity||Human, Mouse, Zebrafish, Hamster, Pig, Chicken, Xenopus, Dog|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Oligosaccharyltransferase complex subunit OSTC, Hydrophobic protein HSF-28, OSTC|
|Target/Specificity||Human OSTC. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||OSTC Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as substrate-specific component of the N- oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.|
|Cellular Location||Endoplasmic reticulum. Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Favier A.-L.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
Zhao Z.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Ye M.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Peng Y.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
Brandenberger R.,et al.Nat. Biotechnol. 22:707-716(2004).
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