|Dilution||IHC-P (10 µg/ml)|
|Other Names||Oligosaccharyltransferase complex subunit OSTC, Hydrophobic protein HSF-28, OSTC|
|Target/Specificity||Human OSTC. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||OSTC Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.|
|Cellular Location||Endoplasmic reticulum. Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Favier A.-L.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
Zhao Z.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Ye M.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Peng Y.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
Brandenberger R.,et al.Nat. Biotechnol. 22:707-716(2004).
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