|Application ||IHC-P, E|
|Dilution||ELISA (1:1000), IHC-P (20 µg/ml),|
|Other Names||Pro-neuregulin-3, membrane-bound isoform, Pro-NRG3, Neuregulin-3, NRG-3, NRG3|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NRG3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.|
|Cellular Location||Pro-neuregulin-3, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form|
|Tissue Location||Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Zhang D.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:9562-9567(1997).
Carteron C.,et al.J. Cell Sci. 119:898-909(2006).
Tiao J.Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 429:375-381(2004).
Sweeney C.,et al.J. Biol. Chem. 275:19803-19807(2000).
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