|Application ||WB, IHC-P, IF, ICC|
|Dilution||IHC-P (5 µg/ml), WB (0.5-1 µg/ml),|
|Other Names||Caspase-5, CASP-5, 220.127.116.11, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p20, Caspase-5 subunit p10, CASP5, ICH3|
|Target/Specificity||14 amino acid peptide from the center of human Caspase-5|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||CASP5 / Caspase 5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).|
|Tissue Location||Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Mediator of programmed cell death (apoptosis).
Eckhart L.,et al.Biochem. Biophys. Res. Commun. 348:682-688(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Munday N.A.,et al.J. Biol. Chem. 270:15870-15876(1995).
Faucheu C.,et al.Eur. J. Biochem. 236:207-213(1996).
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