|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog|
|Dilution||IHC-P (10 µg/ml), WB (0.5-1 µg/ml),|
|Other Names||Protein fem-1 homolog B, FEM1b, FEM1-beta, Fem-1-like death receptor-binding protein alpha, Fem-1-like in apoptotic pathway protein alpha, F1A-alpha, FEM1B, F1AA, KIAA0396|
|Target/Specificity||Peptide (DINYQDQIPRTLEE) corresponding to amino acids 609 to 622 of human F1Aa This sequence is identical to the corresponding sequence of mouse FEM1b.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||FEM1B Antibody (aa609-622) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.|
|Cellular Location||Cytoplasm. Nucleus. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin|
|Tissue Location||Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.|
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Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Chan S.-L.,et al.J. Biol. Chem. 274:32461-32468(1999).
Ventura-Holman T.,et al.Biochem. Biophys. Res. Commun. 267:317-320(2000).
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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