|Application ||WB, IHC-P, E|
|Dilution||IHC-P (1-5 µg/ml)|
|Other Names||Sphingosine kinase 2, SK 2, SPK 2, 18.104.22.168, SPHK2|
|Target/Specificity||Peptide from the N-terminus of human SPHK2 (long form)|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||SPHK2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides.|
|Cellular Location||Isoform 1: Cytoplasm. Membrane.|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides.
Liu H.,et al.J. Biol. Chem. 275:19513-19520(2000).
Alemany R.,et al.Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
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