|Application ||WB, IHC-P, ICC|
|Dilution||IHC-P (5 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Toll-like receptor 8, CD288, TLR8|
|Target/Specificity||peptide corresponding to 16 amino acids near the middle of human TLR8|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||TLR8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Du X.,et al.Eur. Cytokine Netw. 11:362-371(2000).
Chuang T.-H.,et al.Eur. Cytokine Netw. 11:372-378(2000).
Nakajima T.,et al.Immunogenetics 60:727-735(2008).
Georgel P.,et al.PLoS ONE 4:E7803-E7803(2009).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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