|Application ||WB, IHC-P, IF, E, IHC-Fr|
|Clone Names||8C6, 8C6D4B1|
|Dilution||ELISA (1:10000), IHC-Fr (1:200-1:1000), IHC-P (1:200-1:1000), WB (1:200-1:1000) ,|
|Other Names||Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3|
|Target/Specificity||Ni-NTA purified recombinant protein MCL-1expressed in E. Coli strain M15|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||MCL1 / MCL 1 Antibody (clone 8C6, 8C6D4B1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.|
|Cellular Location||Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Kozopas K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3516-3520(1993).
Umezawa A.,et al.Cell Struct. Funct. 21:143-150(1996).
Akgul C.,et al.Cell. Mol. Life Sci. 57:684-691(2000).
Bingle C.D.,et al.J. Biol. Chem. 275:22136-22146(2000).
Bae J.,et al.J. Biol. Chem. 275:25255-25261(2000).
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