|Application ||IHC-P, E|
|Dilution||ELISA (1:16000), IHC-P (2.5 µg/ml),|
|Other Names||DNA cross-link repair 1A protein, SNM1 homolog A, hSNM1, hSNM1A, DCLRE1A, KIAA0086, SNM1, SNM1A|
|Target/Specificity||Human DCLRE1A / SNM1.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||DCLRE1A / SNM1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0086, SNM1, SNM1A|
|Function||May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.|
|Cellular Location||Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross- linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1|
|Tissue Location||Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.
Nagase T.,et al.DNA Res. 2:37-43(1995).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Dronkert M.L.G.,et al.Mol. Cell. Biol. 20:4553-4561(2000).
Zhang X.,et al.DNA Repair 1:379-390(2002).
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