|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (1-2 µg/ml),|
|Other Names||Interstitial collagenase, 220.127.116.11, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1, 22 kDa interstitial collagenase, 27 kDa interstitial collagenase, MMP1, CLG|
|Target/Specificity||Synthetic collagenase-1 peptide derived from the hinge region of human MMP-1|
|Reconstitution & Storage||+4°C, avoid freezing|
|Precautions||MMP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Templeton N.S.,et al.Cancer Res. 50:5431-5437(1990).
Whitham S.E.,et al.Biochem. J. 240:913-916(1986).
Goldberg G.I.,et al.J. Biol. Chem. 261:6600-6605(1986).
Lin D.,et al.Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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