|Application ||IHC-P, Flo|
|Calculated MW||33349 Da|
|Dilution||Flo (0.5 µg/10E6 cells), IHC-P (1:50),|
|Other Names||ICOS ligand, B7 homolog 2, B7-H2, B7-like protein Gl50, B7-related protein 1, B7RP-1, CD275, ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653|
|Reconstitution & Storage||+4°C. Store undiluted.|
|Precautions||ICOSLG / ICOSL / ICOS Ligand Antibody (clone 2D3) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||B7H2, B7RP1, ICOSL, KIAA0653|
|Function||Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.|
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