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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DCAF6 / NRIP Antibody (aa800-850)   

DCAF6 / NRIP Antibody (aa800-850)

Rabbit Polyclonal Antibody

  • WB - DCAF6 / NRIP Antibody (aa800-850) ALS12089
    Western blot of NRIP in human muscle tissue lysate in the 1) absence and 2) presence of...
  • IHC - DCAF6 / NRIP Antibody (aa800-850) ALS12089
    Anti-DCAF6 / NRIP antibody IHC of human skeletal muscle.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q58WW2
Reactivity Human, Mouse, Rat, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 96kDa
Dilution IHC-P (10 µg/ml), WB (1-3 µg/ml),
Additional Information
Other Names DDB1- and CUL4-associated factor 6, Androgen receptor complex-associated protein, ARCAP, IQ motif and WD repeat-containing protein 1, Nuclear receptor interaction protein, NRIP, DCAF6, IQWD1
Target/Specificity A portion of amino acids 800-850 of human NRIP was used as the immunogen.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsDCAF6 / NRIP Antibody (aa800-850) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCAF6
Synonyms IQWD1
Function Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Cellular Location Nucleus.
Tissue Location Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland. EMBL; AY766164; AAX09330.1; -; mRNA EMBL; DQ768089; ABG76793.1; -; mRNA EMBL; AF116725; AAO15301.1; -; mRNA EMBL; AK297847; BAG60180.1; -; mRNA EMBL; Z97876; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL033531; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL031287; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL033532; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471067; EAW90809.1; -; Genomic_DNA EMBL; BC025262; AAH25262.2; -; mRNA EMBL; AL136738; CAB66672.2; -; mRNA CCDS; CCDS1267.2; -. [Q58WW2-2] CCDS; CCDS30933.1; -. [Q58WW2-1] CCDS; CCDS55657.1; -. [Q58WW2-3] CCDS; CCDS55658.1; -. [Q58WW2-4] RefSeq; NP_001017977.1; NM_001017977.2. [Q58WW2-1] RefSeq; NP_001185885.1; NM_001198956.1. [Q58WW2-3] RefSeq; NP_001185886.1; NM_001198957.1. [Q58WW2-4] RefSeq; NP_060912.2; NM_018442.3. [Q58WW2-2] UniGene; Hs.435741; - PDB; 3I7O; X-ray; 2.80 A; B=9-21 PDBsum; 3I7O; - ProteinModelPortal; Q58WW2; - SMR; Q58WW2; - BioGrid; 120933; 52 DIP; DIP-44678N; - IntAct; Q58WW2; 15 MINT; Q58WW2; - STRING; 9606.ENSP00000356814; - iPTMnet; Q58WW2; - PhosphoSitePlus; Q58WW2; - BioMuta; DCAF6; - DMDM; 74755134; - EPD; Q58WW2; - MaxQB; Q58WW2; - PaxDb; Q58WW2; - PeptideAtlas; Q58WW2; - PRIDE; Q58WW2; - ProteomicsDB; 62628; - ProteomicsDB; 62629; -. [Q58WW2-2] ProteomicsDB; 62630; -. [Q58WW2-3] ProteomicsDB; 62631; -. [Q58WW2-4] DNASU; 55827; - Ensembl; ENST00000312263; ENSP00000311949; ENSG00000143164. [Q58WW2-1] Ensembl; ENST00000367840; ENSP00000356814; ENSG00000143164. [Q58WW2-3] Ensembl; ENST00000367843; ENSP00000356817; ENSG00000143164. [Q58WW2-2] Ensembl; ENST00000432587; ENSP00000396238; ENSG00000143164. [Q58WW2-4] GeneID; 55827; - KEGG; hsa:55827; - UCSC; uc001gev.5; human. [Q58WW2-1] CTD; 55827; - DisGeNET; 55827; - EuPathDB; HostDB:ENSG00000143164.15; - GeneCards; DCAF6; - HGNC; HGNC:30002; DCAF6 HPA; HPA054305; - MIM; 610494; gene neXtProt; NX_Q58WW2; - OpenTargets; ENSG00000143164; - PharmGKB; PA165751150; - eggNOG; KOG1310; Eukaryota eggNOG; KOG1334; Eukaryota eggNOG; ENOG410XQZP; LUCA GeneTree; ENSGT00530000062951; - HOGENOM; HOG000038027; - HOVERGEN; HBG054871; - InParanoid; Q58WW2; - KO; K11795; - OMA; QTEAIGP; - OrthoDB; EOG091G01Z0; - PhylomeDB; Q58WW2; - TreeFam; TF326071; - Reactome; R-HSA-8951664; Neddylation SignaLink; Q58WW2; - UniPathway; UPA00143; - ChiTaRS; DCAF6; human EvolutionaryTrace; Q58WW2; - GenomeRNAi; 55827; - PRO; PR:Q58WW2; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000143164; - CleanEx; HS_IQWD1; - ExpressionAtlas; Q58WW2; baseline and differential Genevisible; Q58WW2; HS GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IDA:UniProtKB GO; GO:0005829; C:cytosol; IDA:HPA GO; GO:0005925; C:focal adhesion; IDA:HPA GO; GO:0005654; C:nucleoplasm; TAS:Reactome GO; GO:0005634; C:nucleus; IDA:HPA GO; GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:MGI GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:MGI GO; GO:0043687; P:post-translational protein modification; TAS:Reactome GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway Gene3D;; -; 2 InterPro; IPR000048; IQ_motif_EF-hand-BS InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf InterPro; IPR001680; WD40_repeat InterPro; IPR017986; WD40_repeat_dom InterPro; IPR036322; WD40_repeat_dom_sf Pfam; PF00400; WD40; 2 SMART; SM00320; WD40; 7 SUPFAM; SSF50978; SSF50978; 2 PROSITE; PS50096; IQ; 1 PROSITE; PS50294; WD_REPEATS_REGION; 2 1: Evidence at protein level; 3D-structure; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat CHAIN 1 860 DDB1- and CUL4-associated factor 6 /FTId=PRO_0000304401 REPEAT 49 88 WD 1 REPEAT 92 133 WD 2 REPEAT 139 179 WD 3 REPEAT 189 229 WD 4 REPEAT 251 290 WD 5 DOMAIN 676 705 IQ. {ECO:0000255|PROSITE- ProRule:PRU00116} REPEAT 718 756 WD 6 REPEAT 759 798 WD 7 MOD_RES 336 336 Phosphoserine MOD_RES 649 649 Phosphoserine MOD_RES 654 654 Phosphothreonine MOD_RES 657 657 Phosphoserine MOD_RES 847 847 Phosphoserine {ECO:0000250|UniProtKB:Q9DC22} MOD_RES 850 850 Phosphoserine {ECO:0000250|UniProtKB:Q9DC22} VAR_SEQ 54 84 Missing (in isoform 4) /FTId=VSP_043312 VAR_SEQ 459 459 S -> SDSPSSVVNKQLGSMSLDEQQ (in isoform 2). /FTId=VSP_028019 VAR_SEQ 459 459 S -> SEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHT QQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQ Q (in isoform 3 and isoform 4) {ECO:0000303|PubMed:14702039, ECO:0000303|Ref.3} /FTId=VSP_028020 VAR_SEQ 675 675 D -> DRFNIRGTTIGDRIM (in isoform 3 and isoform 4). {ECO:0000303|PubMed:14702039, ECO:0000303|Ref.3} /FTId=VSP_028021 VARIANT 547 547 V -> A (in dbSNP:rs11558511) /FTId=VAR_035020 HELIX 10 18 {ECO:0000244|PDB:3I7O} SEQUENCE 860 AA; 96292 MW; 8C7602D635DAF124 CRC64; MSRGGSYPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH DGCVNTICWN DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA KFLPCTNDKQ IVSCSGDGVI FYTNVEQDAE TNRQCQFTCH YGTTYEIMTV PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE DCKDDILINC RRAATSVAIC PPIPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM VARFIPSHLN NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS RWFEEASEVA QSNRGRGRSR PRGGTSQSDI STLPTVPSSP DLEVSETAME VDTPAEQFLQ PSTSSTMSAQ AHSTSSPTES PHSTPLLSSP DSEQRQSVEA SGHHTHHQSD NNNEKLSPKP GTGEPVLSLH YSTEGTTTST IKLNFTDEWS SIASSSRGIG SHCKSEGQEE SFVPQSSVQP PEGDSETKAP EESSEDVTKY QEGVSAENPV ENHINITQSD KFTAKPLDSN SGERNDLNLD RSCGVPEESA SSEKAKEPET SDQTSTESAT NENNTNPEPQ FQTEATGPSA HEETSTRDSA LQDTDDSDDD PVLIPGARYR AGPGDRRSAV ARIQEFFRRR KERKEMEELD TLNIRRPLVK MVYKGHRNSR TMIKEANFWG ANFVMSGSDC GHIFIWDRHT AEHLMLLEAD NHVVNCLQPH PFDPILASSG IDYDIKIWSP LEESRIFNRK LADEVITRNE LMLEETRNTI TVPASFMLRM LASLNHIRAD RLEGDRSEGS GQENENEDEE
Research Areas
Citations (0)

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Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.


Tsai T.C.,et al.J. Biol. Chem. 280:20000-20009(2005).
Chang T.-J.,et al.Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
Zhao B.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 425.00
Cat# ALS12089
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