|Application ||IHC-P, E|
|Calculated MW||67033 Da|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||C4b-binding protein alpha chain, C4bp, Proline-rich protein, PRP, C4BPA, C4BP|
|Target/Specificity||Recognizes complement component 4 binding protein (C4bp). There are three variants of C4bp, composed of alpha and beta chains. The predominant form is a 570 kD complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kD homohe ...|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing. Store undiluted.|
|Precautions||C4BP / C4b-Binding Protein Antibody (clone 10-07) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.|
|Tissue Location||Chylomicrons in the plasma.|
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