|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Bovine, Dog|
|Dilution||ELISA (1:64000), IHC-P (5 µg/ml), WB (0.2-0.6 µg/ml)|
|Other Names||PTB domain-containing engulfment adapter protein 1, Cell death protein 6 homolog, PTB domain adapter protein CED-6, Protein GULP, GULP1, CED6, GULP|
|Target/Specificity||Human GULP1 / CED6.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CED6 / GULP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.|
|Cellular Location||Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes|
|Tissue Location||Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.|
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May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Liu Q.A.,et al.Curr. Biol. 9:1347-1350(1999).
Smits E.,et al.Curr. Biol. 9:1351-1354(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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