|Application ||WB, IHC-P|
|Dilution||IHC-P (5 µg/ml), WB (0.5-4 µg/ml),|
|Other Names||Interleukin-18, IL-18, Iboctadekin, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, IL18, IGIF, IL1F4|
|Reconstitution & Storage||Long term: -70°C; Short term: -20°C; Avoid freeze-thaw cycles.|
|Precautions||IL18 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
Ushio S.,et al.J. Immunol. 156:4274-4279(1996).
Gaggero A.,et al.Oncogene 23:7552-7560(2004).
Yong D.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Liu J.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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