|Application ||IHC-P, E, RIA|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1, Proapolipoprotein A-I, ProapoA-I, Truncated apolipoprotein A-I, Apolipoprotein A-I(1-242), APOA1|
|Target/Specificity||Recognizes Apolipoprotein A-I (Apo A-I). This antibody does not cross-react with Apo A-II or Apo B in competitive RIA.|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||APOA1 / Apolipoprotein A 1 Antibody (clone 057-10029) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.|
|Tissue Location||Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Shoulders C.C.,et al.Nucleic Acids Res. 11:2827-2837(1983).
Cheung P.,et al.Nucleic Acids Res. 11:3703-3715(1983).
Karathanasis S.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:6147-6151(1983).
Seilhamer J.J.,et al.DNA 3:309-317(1984).
Sharpe C.R.,et al.Nucleic Acids Res. 12:3917-3932(1984).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.