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PARP2 Antibody (Internal)

Goat Polyclonal Antibody

  • IHC - PARP2 Antibody (Internal) ALS12716
    Anti-PARP2 antibody IHC of human adrenal.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UGN5
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 66kDa
Dilution ELISA (1:8000), IHC-P (2.5 µg/ml), WB (1:8000)
Additional Information
Gene ID 10038
Other Names Poly [ADP-ribose] polymerase 2, PARP-2, hPARP-2,, ADP-ribosyltransferase diphtheria toxin-like 2, ARTD2, NAD(+) ADP-ribosyltransferase 2, ADPRT-2, Poly[ADP-ribose] synthase 2, pADPRT-2, PARP2, ADPRT2, ADPRTL2
Target/Specificity Human PARP2.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsPARP2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PARP2
Synonyms ADPRT2, ADPRTL2
Function Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:28190768, PubMed:25043379). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379). ADP- ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Also mediates serine ADP- ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034).
Cellular Location Nucleus.
Tissue Location Widely expressed, mainly in actively dividing tissues (PubMed:10364231). The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus (PubMed:10364231).
Citations (0)

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Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.


Ame J.-C.,et al.J. Biol. Chem. 274:17860-17868(1999).
Johansson M.,et al.Genomics 57:442-445(1999).
Berghammer H.,et al.FEBS Lett. 449:259-263(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schreiber V.,et al.J. Biol. Chem. 277:23028-23036(2002).

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$ 467.50
Cat# ALS12716
Availability: 5 days
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