|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000)|
|Other Names||Tyrosine-protein kinase STYK1, 188.8.131.52, Novel oncogene with kinase domain, Protein PK-unique, Serine/threonine/tyrosine kinase 1, STYK1, NOK|
|Target/Specificity||Ni-NTA purified truncated recombinant STYK1-His is expressed in E. Coli strain BL21 (DE3)|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||STYK1 Antibody (clone 2H2F10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers|
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Provided below are standard protocols that you may find useful for product applications.
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
Ye X.,et al.Mol. Biol. Rep. 30:91-96(2003).
Liu L.,et al.Cancer Res. 64:3491-3499(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherer S.E.,et al.Nature 440:346-351(2006).
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