|Application ||IHC-P, IF|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Chicken, Sheep, Horse, Bovine, Dog|
|Other Names||Troponin T, cardiac muscle, TnTc, Cardiac muscle troponin T, cTnT, TNNT2|
|Target/Specificity||Recognizes the cardiac isoform of rabbit Troponin T (cTnT). Species cross-reactivity: Canine, chicken, goldfish, guinea pig, human, mouse, porcine, rat, sparrow. Does not react with frog.|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||TNNT2 / CTNT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
|Tissue Location||Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart|
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Provided below are standard protocols that you may find useful for product applications.
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Mesnard L.,et al.FEBS Lett. 328:139-144(1993).
Townsend P.J.,et al.Genomics 21:311-316(1994).
Townsend P.J.,et al.J. Mol. Cell. Cardiol. 27:2223-2236(1995).
Anderson P.A.,et al.Circ. Res. 76:681-686(1995).
Mesnard L.,et al.Circ. Res. 76:687-692(1995).
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