|Application ||WB, IHC-P, IHC-Fr, Flo|
|Dilution||IHC-Fr, IHC-P (20 µg/ml),|
|Other Names||Integrin beta-4, GP150, CD104, ITGB4|
|Reconstitution & Storage||Store at 4°C, avoid repeated freeze thaw cycles.|
|Precautions||ITGB4 / Integrin Beta 4 Antibody (clone 439-9B) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes|
|Tissue Location||Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.
Suzuki S.,et al.EMBO J. 9:757-763(1990).
Hogervorst F.,et al.EMBO J. 9:765-770(1990).
Tamura R.N.,et al.J. Cell Biol. 111:1593-1604(1990).
Pulkkinen L.,et al.Lab. Invest. 76:823-833(1997).
Iacovacci S.,et al.Mamm. Genome 8:448-450(1997).
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