|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Inactive caspase-12, CASP-12, CASP12|
|Target/Specificity||synthetic peptide corresponding to amino acids within the large cleavage product of murine caspase-12|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||CASP12 / Caspase 12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.|
|Tissue Location||Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis|
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Provided below are standard protocols that you may find useful for product applications.
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Fischer H.,et al.Biochem. Biophys. Res. Commun. 293:722-726(2002).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Taylor T.D.,et al.Nature 440:497-500(2006).
Saleh M.,et al.Nature 429:75-79(2004).
Kachapati K.,et al.Hum. Mutat. 27:975-975(2006).
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